Many abnormalities in brain function have direct or indirect effects on synaptic function or originate from synaptic dysfunction 2, 3, 4, 5, 6. Synapses are asymmetric intercellular junctions between neurons, which are crucial for transforming and transmitting signals 1. We also found a structure–activity relationship for designing novel potent histone deacetylase inhibitors, which can be applied towards development of new therapeutics. Using this technology, we screened a chemical library, and identified novel histone deacetylase (HDAC) inhibitors that improve neuroligin-1-induced synaptogenesis by modulating class-I HDACs. It is readily incorporated into multiwell formats compatible with industrial high-throughput screening platforms. The technology increases by tenfold the sensitivity of the traditional assays, and simultaneously decreases the time required to capture synaptogenic events by an order of magnitude. Our platform enables the induction of synaptic structures in regular arrays by precise positioning of non-neuronal cells expressing synaptic proteins, while allowing neurites to grow freely around these cells. Here we report a 'synapse microarray' technology that enables ultra-sensitive, high-throughput and quantitative screening of synaptogenesis. Technologies for large-scale synapse assays can facilitate identification of drug leads. We’ve won countless awards for our unrivalled technical expertise on the Microsoft platform, and for the innovative thinking that goes into our work.Synaptic function is affected in many brain diseases and disorders. Avanade delivers the benefits of Azure SynapseĪvanade delivers on the benefits of Azure Synapse Analytics with deep integration and delivery expertise across industries to help our clients quickly uncover the value from their data with cloud scale analytics.
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